What does “high sensitivity” mean in the context of cardiac troponin testing? What qualifies an assay to be designated 4th generation, 5th generation etc.?
A new season for cardiac troponin assays: it’s time to keep a scorecard.
Apple FS. Clin Chem 2009;55(7):1303-1306. DOI: 10.1373/clinchem.2009.128363

Use of a universal sample bank enables systematic comparison of results from different assays.
Creation of a universal sample bank for determining the 99th percentile for cardiac troponin assays.
Wu AHB, Apple F, Love SA, Koch D, Myers GL, Christenson RH, on behalf of the AACC’s Biomarkers of Acute Cardiovascular Disease Division. J Appl Lab Med 2017;1(6):711-719. DOI: 10.1373/jalm.2016.022897

Of equal importance to the definition of “high sensitivity” troponin testing is a unified set of criteria to reduce ambiguity in clinical guidelines.
Fourth Universal Definition of Myocardial Infarction.
Thygesen K, Alpert JS, Jaffe AS, et al. Fourth Universal Definition of Myocardial Infarction. Circulation 2018;138:618-651. DOI: 10.1161/CIR.0000000000000617

Here is a clinician’s point of view.
Using high-sensitivity cardiac troponin T for acute cardiac care.
Sandoval Y, Jaffe AS. Am J Med 2017;130(12):1358-1365. DOI: https://doi.org/10.1016/j.amjmed.2017.07.033

With expanding clinical utility, the need for testing at the point of care emerges, and demand for tests that use whole blood samples is not far behind.
Performance characteristics of a high-sensitivity cardiac troponin assay using plasma and whole blood samples.
Li P, Enea NS, Zuk R, Tan H, Wu AHB, Jaffe AS. Clin Biochem 2017;50(18):1249-1252. DOI: 10.1016/j.clinbiochem.2017.08.002